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The crude product is purified by preparative liquid chromatography using a C 18 stationary phase with eluent A: 0.1 % TFA in water and eluent B: 0.1 % TFA in acetonitrile. In general oxytetracycline and tetracycline could be more readily quantified at lower levels than could Chlortetracycline.
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The present invention pertains, at least in part, to novel substituted tetracycline compounds.
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